Functional Analysis of Drosophila TCTP Regulating Immune SignalingPathway to Enhance Cell Tolerance to Deltamethrin

Nov 3, 2023

B.Sc. Graduation Project

Supervisor: Prof. Luogen Cheng

Translationally controlled tumor protein(TCTP) is a multifunctional protein that is highly conserved in a variety of species. TCTP expression is highly regulated and affects many life processes such as cell growth and differentiation. Since the expression of TCTP was upregulated in drug-resistant insects, we analyzed the effect of TCTP on the expression of drsl1, a gene downstream of the Toll-like receptor signaling pathway, to investigate the regulatory role of TCTP on cellular tolerance. 

  • Studying the relationship between resistance of Drosophila cells to Deltamethrin and TCTP expression 
  • Overexpression and interference of TCTP gene in Drosophila cells 
  • Analyzing the changes of TCTP expression levels in cells and their effects on gene drsl1 by qPCR 
Before 2022
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Lingkai Dong

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