Vesicle-like polydopamine nanomaterials with high viscosity for more efficient T cell activation

Supervisor: Prof. Tiancong Zhao, Prof. Dongyuan Zhao

Nanoscale artificial antigen-presenting cells(aAPCs) are often used for T cell activation in vivo or in vitro. Previous studies have shown that differences in topology (e.g. morphology, hardness) of nanomaterials can result in different T cell activation efficacy. In this work, we designed artificial antigen-presenting cells based on a novel highly viscous vesicle-like polydopamine Cap, which shown better T cell activation efficiency compared to spherical nanoparticles.

• Preparation of BSA/antibodies-modified polydopamine Cap and NPs
• Cellular uptake assay of PDA Cap and NPs
• Co-culture of aAPCs with Jurkat for T cell activation analysis